voltage-gated sodium channels — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15260	Evenamide	NW-3509	Sodium Channel
	Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.		Sodium Channel
T0939	Phenytoin	Diphenylhydantoin,5,5-Diphenylhydantoin	Virus Protease , Sodium Channel
	Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor...		Virus Protease , Sodium Channel
T0008	Phenytoin sodium	5,5-Diphenylhydantoin sodium salt,Diphantoine,Dilantin sodium,Diphenylhydantoin Sodium	Virus Protease , Sodium Channel
	Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .		Virus Protease , Sodium Channel
T19723	AMTB hydrochloride	AMTB	TRP/TRPV Channel
	AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl...		TRP/TRPV Channel
T7806	Licarbazepine	10,11-hydroxy-10,11 Dihydrocarbamezer	Others
	Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders.		Others
T2173	Veratridine		Sodium Channel
	Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.		Sodium Channel
T9751	Transfluthrin		Others
	Transfluthrin is a volatile pyrethroid insecticide that targets insect voltage-gated sodium channels (VGSC).		Others
T0796	Prilocaine hydrochloride	Prilocaine HCl,Propitocaine hydrochloride,Xylonest	ATPase , Sodium Channel
	Prilocaine hydrochloride (Prilocaine HCl) is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions.		ATPase , Sodium Channel
T0018	Procainamide hydrochloride	Procapan,Procainamide HCl,Pronestyl,Procanbid	DNA Methyltransferase , Sodium Channel , AChR , Autophagy
	Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to...		DNA Methyltransferase , Sodium Channel , AChR , Autophagy
T22361	Mepivacaine	Carbocaine	Sodium Channel
	Mepivacaine (Carbocaine) is an amide compound for local anaesthesia that causes transient loss of self-consciousness in humans or animals. mepivacaine acts by binding to specific voltage-gated sodium channels in nerve ce...		Sodium Channel
T7502	PF 05089771 tosylate		Sodium Channel
	PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8...		Sodium Channel
T1496	Amiodarone hydrochloride	Amiodar,Amiodarone HCl,Nexterone	Potassium Channel , Adrenergic Receptor , Autophagy
	Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM C...		Potassium Channel , Adrenergic Receptor , Autophagy
TN1254	3'-Methoxydaidzein		Sodium Channel
	3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla...		Sodium Channel
T0267	Zonisamide	AD 810,CI 912	Calcium Channel , Sodium Channel , Carbonic Anhydrase
	Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms...		Calcium Channel , Sodium Channel , Carbonic Anhydrase
T27040	Clathrodin
	Clathrodin is a voltage-gated sodium (NaV) channels modulator.
T13830	Propoxycaine hydrochloride		Sodium Channel
	Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels.		Sodium Channel
T26564	ADCI	SGB-017,SGB017,SGB 017
	ADCI is an inhibitor of voltage-activated sodium channels and N-methyl-D-aspartate (NMDA)-receptor-gated channels. Inhibition of sodium channels by ADCI was voltage dependent. High doses of ADCI increased dopamine metabo...
T70224	Bupivacaine tartrate
	Bupivacaine is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intra...
T82700	Cn2 toxin	β-Mammal toxin Cn2
	Cn2 toxin, a β-toxin, interacts with the voltage-sensing domain of voltage-gated sodium channels (NaV) [1].
TP1967	Phrixotoxin 3
	Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV1.2, NaV1.3 and NaV1.5 respectively). Blocks inward sodium currents in a voltage-dependent manner.